An ex vivo model of Toxoplasma recrudescence reveals developmental plasticity of the bradyzoite stage.
mBio
; 14(5): e0183623, 2023 Oct 31.
Article
in En
| MEDLINE
| ID: mdl-37675999
ABSTRACT
IMPORTANCE The classical depiction of the Toxoplasma lifecycle is bradyzoite excystation conversion to tachyzoites, cell lysis, and immune control, followed by the reestablishment of bradyzoites and cysts. In contrast, we show that tachyzoite growth slows independent of the host immune response at a predictable time point following excystation. Furthermore, we demonstrate a host cell-dependent pathway of continuous amplification of the cyst-forming bradyzoite population. The developmental plasticity of the excysted bradyzoites further underlines the critical role the cyst plays in the flexibility of the lifecycle of this ubiquitous parasite. This revised model of Toxoplasma recrudescence uncovers previously unknown complexity in the clinically important bradyzoite stage of the parasite, which opens the door to further study these novel developmental features of the Toxoplasma intermediate life cycle.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Toxoplasma
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
MBio
Year:
2023
Document type:
Article
Affiliation country: