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Nanomolar range of FAM237B can activate receptor GPR83.
Li, Hao-Zheng; Wang, Ya-Fen; Hu, Wen-Feng; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun.
Affiliation
  • Li HZ; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
  • Wang YF; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
  • Hu WF; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
  • Liu YL; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
  • Xu ZG; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
  • Guo ZY; Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China. zhan-yun.guo@tongji.edu.cn.
Amino Acids ; 55(11): 1557-1562, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37689599
ABSTRACT
Our recent study confirmed that the mature neuropeptide FAM237A, also known as neurosecretory protein GL (NPGL), is an efficient agonist for GPR83. The paralog FAM237B was previously reported as a weak agonist for GPR83. In the present study, we prepared mature human FAM237B via an intein-fusion approach and demonstrated that it could cause a significant activation effect at the nanomolar range (1‒10 nM) in a NanoBiT-based ß-arrestin recruitment assay. Thus, FAM237B appears to be another endogenous agonist for GPR83 and future in vivo studies will be required to confirm this.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Receptors, G-Protein-Coupled Limits: Humans Language: En Journal: Amino Acids Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Receptors, G-Protein-Coupled Limits: Humans Language: En Journal: Amino Acids Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country: