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The emerging role of the urinary microbiome in benign noninfectious urological conditions: an up-to-date systematic review.
Suarez Arbelaez, Maria Camila; Monshine, Joshua; Porto, Joao G; Shah, Khushi; Singh, Praveen K; Roy, Sabita; Amin, Katherine; Marcovich, Robert; Herrmann, Thomas R W; Shah, Hemendra N.
Affiliation
  • Suarez Arbelaez MC; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Monshine J; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Porto JG; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Shah K; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Singh PK; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Roy S; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Amin K; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Marcovich R; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Herrmann TRW; Switzerland Urology Spitial Thurgau AG (STGAG), Frauenfeld, Switzerland.
  • Shah HN; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA. drhemendrashah@yahoo.co.in.
World J Urol ; 41(11): 2933-2948, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37737900
PURPOSE: The goal of this systematic review was to examine the current literature on the urinary microbiome and its associations with noninfectious, nonmalignant, urologic diseases. Secondarily, we aimed to describe the most common bioinformatics used to analyze the urinary microbiome. METHODS: A comprehensive literature search of Ovid MEDLINE using the keywords "microbiota" AND "prostatic hyperplasia," "microbiota" AND "urinary bladder, overactive," "microbiota" AND "pelvic pain," and "microbiota" AND "urolithiasis" OR "nephrolithiasis" OR "urinary calculi" AND "calcium oxalate" was performed to identify relevant clinical microbiome studies associated with noninfectious benign urological conditions published from 2010 to 2022. We included human studies that evaluated the urinary, stone, or semen microbiota, or any combination of the above-mentioned locations. RESULTS: A total of 25 human studies met the inclusion criteria: 4 on benign prostatic hyperplasia (BPH), 9 on overactive bladder (OAB), 8 on calcium oxalate stones, and 4 on chronic pelvic pain syndrome (CPPS). Specific taxonomic profiles in the urine microbiome were associated with each pathology, and evaluation of alpha- and beta-diversity and relative abundance was accounted for most of the studies. Symptom prevalence and severity were also analyzed and showed associations with specific microbes. CONCLUSION: The study of the urogenital microbiome is rapidly expanding in urology. Noninfectious benign urogenital diseases, such as BPH, calcium oxalate stones, CPPS, and OAB were found to be associated with specific microbial taxonomies. Further research with larger study populations is necessary to solidify the knowledge of the urine microbiome in these conditions and to facilitate the creation of microbiome-based diagnostic and therapeutic approaches.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Urinary Calculi / Urinary Bladder, Overactive / Microbiota Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans / Male Language: En Journal: World J Urol Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Urinary Calculi / Urinary Bladder, Overactive / Microbiota Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans / Male Language: En Journal: World J Urol Year: 2023 Document type: Article Affiliation country: Country of publication: