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Lambert-Eaton Myasthenic Syndrome Complicated by anti-GABAB Receptor Encephalitis.
Yamada, Kazuki; Yaguchi, Hiroaki; Ishikawa, Kaede; Tanaka, Daiki; Oshima, Yuki; Mizushima, Keiichi; Uwatoko, Hisashi; Shirai, Shinichi; Iwata, Ikuko; Matsushima, Masaaki; Tanaka, Keiko; Yabe, Ichiro.
Affiliation
  • Yamada K; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Yaguchi H; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Ishikawa K; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Tanaka D; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Oshima Y; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Mizushima K; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Uwatoko H; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Shirai S; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Iwata I; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Matsushima M; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Tanaka K; Department of Animal Model Development, Brain Research Institute, Niigata University, Japan.
  • Yabe I; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Intern Med ; 2023 Sep 22.
Article in En | MEDLINE | ID: mdl-37743510
A 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country: Country of publication: