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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints.
Yin, Zhuoran; Rosenzweig, Neta; Kleemann, Kilian L; Zhang, Xiaoming; Brandão, Wesley; Margeta, Milica A; Schroeder, Caitlin; Sivanathan, Kisha N; Silveira, Sebastian; Gauthier, Christian; Mallah, Dania; Pitts, Kristen M; Durao, Ana; Herron, Shawn; Shorey, Hannah; Cheng, Yiran; Barry, Jen-Li; Krishnan, Rajesh K; Wakelin, Sam; Rhee, Jared; Yung, Anthony; Aronchik, Michael; Wang, Chao; Jain, Nimansha; Bao, Xin; Gerrits, Emma; Brouwer, Nieske; Deik, Amy; Tenen, Daniel G; Ikezu, Tsuneya; Santander, Nicolas G; McKinsey, Gabriel L; Baufeld, Caroline; Sheppard, Dean; Krasemann, Susanne; Nowarski, Roni; Eggen, Bart J L; Clish, Clary; Tanzi, Rudolph E; Madore, Charlotte; Arnold, Thomas D; Holtzman, David M; Butovsky, Oleg.
Affiliation
  • Yin Z; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Rosenzweig N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Kleemann KL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Zhang X; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Brandão W; School of Computing, University of Portsmouth, Portsmouth, UK.
  • Margeta MA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Schroeder C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Sivanathan KN; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Silveira S; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Gauthier C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Mallah D; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Pitts KM; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Durao A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Herron S; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Shorey H; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Cheng Y; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Barry JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Krishnan RK; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Wakelin S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Rhee J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Yung A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Aronchik M; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Wang C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jain N; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Bao X; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Gerrits E; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Brouwer N; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Deik A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Tenen DG; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Ikezu T; Institute for Brain Science and Disease, Chongqing Medical University, Chongqing, China.
  • Santander NG; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • McKinsey GL; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Baufeld C; Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Sheppard D; Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Krasemann S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Nowarski R; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Eggen BJL; Cancer Science Institute, National University of Singapore, Singapore, Singapore.
  • Clish C; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Tanzi RE; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Madore C; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Arnold TD; Instituto de Ciencias de la Salud, Universidad de O´Higgins, Rancagua, Chile.
  • Holtzman DM; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Butovsky O; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nat Immunol ; 24(11): 1839-1853, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37749326
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: