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Risk factors in underweight older children with sickle cell anemia: a comparison of low- to high-income countries.
Klein, Lauren Jane; Abdullahi, Shehu Umar; Gambo, Safiya; Stallings, Virginia A; Acra, Sari; Rodeghier, Mark; DeBaun, Michael R.
Affiliation
  • Klein LJ; D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
  • Abdullahi SU; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN.
  • Gambo S; Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Stallings VA; Department of Pediatrics, Murtala Mohammed Specialist Hospital, Kano, Nigeria.
  • Acra S; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
  • Rodeghier M; D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
  • DeBaun MR; Rodeghier Consultants, Chicago, IL.
Blood Adv ; 7(22): 6923-6930, 2023 11 28.
Article in En | MEDLINE | ID: mdl-37756514
Previously, we demonstrated that older children with sickle cell anemia (SCA) living in Nigeria are at increased risk of death if they are underweight (weight-for-age z score < -1). We now conducted a cross-sectional study in low- and high-income settings to determine the risk factors for being underweight a in children aged 5 to 12 years with SCA. The children from low- and high-income settings were eligible participants for the Primary Prevention of Stroke in Children with Sickle Cell Disease in Nigeria (SPRING; N = 928) and the Silent Cerebral Infarct (SIT, North America/Europe; N = 1093) trials, respectively. The median age in the SPRING and SIT cohorts was 8.1 and 8.5 years, respectively (P < .001). A total of 87.9% (n = 816) of participants in the SPRING trial (low-income) met the study criteria for being underweight (weight-for-age z score < -1), and 22.7% (n = 211) for severely underweight (weight-for-age z score < -3), significantly higher than the SIT (high-income) cohort at 25.7% underweight (n = 281) and 0.7% severely underweight (n = 8; P < .001 for both comparisons). In the combined cohort, older age (odds ratio [OR], 1.24; P < .001) and lower hemoglobin level (OR, 0.67; P < .001) were associated with being underweight. Age and hemoglobin level remained statistically significant in separate models for the SPRING and SIT cohorts. Older age and lower hemoglobin levels in children aged 5 to 12 years with SCA are associated with being underweight in low- and high-income settings.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thinness / Anemia, Sickle Cell Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Humans Language: En Journal: Blood Adv Year: 2023 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thinness / Anemia, Sickle Cell Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Humans Language: En Journal: Blood Adv Year: 2023 Document type: Article Country of publication: