Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study.
Lupus
; 32(13): 1486-1492, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37852301
ABSTRACT
OBJECTIVE:
To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI).METHODS:
A transverse study with 66 (83.3% female) PAPS patients was performed. All data were evaluated. Patients were subdivided into one of two groups PAPS with LI and PAPS without LI and compared.RESULTS:
Sixty-six primary APS were selected. PAPS with LI group exhibited a longer disease duration (p = .012) and more arterial events (p = .002). A lower frequency of venous events was observed in PAPS with LI (p = .007), and deep venous thrombosis (p = .016). Furthermore, PAPS with LI patients had more deficiency of protein C of coagulation (p = .015) than the others.CONCLUSION:
PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiphospholipid Syndrome
/
Venous Thrombosis
/
Lupus Erythematosus, Systemic
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Lupus
Journal subject:
REUMATOLOGIA
Year:
2023
Document type:
Article
Affiliation country: