Your browser doesn't support javascript.
loading
Viral and immunologic evaluation of smokers with severe COVID-19.
Vecchio, Joseph; Regan, James; Jiang, Yuting; Li, Roy; Romain, Hannah; Yousuf, Fizah; Adel, Thomas; Hall, Kevin; DaCosta, Jeffrey M; Yu, Xu; Li, Jonathan Z; Fofana, Ismael Ben.
Affiliation
  • Vecchio J; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Regan J; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jiang Y; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Li R; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Romain H; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Yousuf F; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Adel T; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Hall K; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • DaCosta JM; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
  • Yu X; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. JLI@bwh.harvard.edu.
  • Fofana IB; Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA. ismael.fofana@bc.edu.
Sci Rep ; 13(1): 17898, 2023 10 19.
Article in En | MEDLINE | ID: mdl-37857680
ABSTRACT
Smoking negatively affects B cell function and immunoglobulin levels, but it is unclear if this immune dysfunction contributes to the risk of severe COVID-19 in smokers. We evaluated binding IgM, IgA and IgG antibodies to spike and receptor binding domain antigens, and used a pseudovirus assay to quantify neutralization titers in a set of 27 patients with severe COVID-19. We found no significant differences between binding and neutralization antibody responses for people with a smoking history and people who never smoked. High plasma viral load, but not antibody titers, was linked to an increased risk of death. Humoral immune dysfunction was not a major driver of severe COVID-19 in smokers.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Sci Rep Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Sci Rep Year: 2023 Document type: Article Affiliation country: