Molecular mechanism of the interaction between Megalocytivirus-induced virus-mock basement membrane (VMBM) and lymphatic endothelial cells.
J Virol
; 97(11): e0048023, 2023 Nov 30.
Article
in En
| MEDLINE
| ID: mdl-37877715
ABSTRACT
IMPORTANCE Viruses are able to mimic the physiological or pathological mechanism of the host to favor their infection and replication. Virus-mock basement membrane (VMBM) is a Megalocytivirus-induced extracellular structure formed on the surface of infected cells and structurally and functionally mimics the basement membrane of the host. VMBM provides specific support for lymphatic endothelial cells (LECs) rather than blood endothelial cells to adhere to the surface of infected cells, which constitutes a unique phenomenon of Megalocytivirus infection. Here, the structure of VMBM and the interactions between VMBM components and LECs have been analyzed at the molecular level. The regulatory effect of VMBM components on the proliferation and migration of LECs has also been explored. This study helps to understand the mechanism of LEC-specific attachment to VMBM and to address the issue of where the LECs come from in the context of Megalocytivirus infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basement Membrane
/
Endothelial Cells
/
Lymphatic Vessels
/
Iridoviridae
Language:
En
Journal:
J Virol
Year:
2023
Document type:
Article
Affiliation country: