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In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis.
Padilha, Elias C; Yang, Mengbi; Shah, Pranav; Wang, Amy Q; Duan, Jianmin; Park, Joshua K; Zawatsky, Charles N; Malicdan, May Christine V; Kunos, George; Iyer, Malliga R; Gaucher, Geneviève; Ravenelle, François; Cinar, Resat; Xu, Xin.
Affiliation
  • Padilha EC; Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA. Electronic address: elias.padilha@nih.gov.
  • Yang M; Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
  • Shah P; Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
  • Wang AQ; Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
  • Duan J; Inversago Pharma, Montreal, Quebec, Canada.
  • Park JK; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
  • Zawatsky CN; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
  • Malicdan MCV; NIH Undiagnosed Diseases Program, UDP Translational Laboratory, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kunos G; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
  • Iyer MR; Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20852, USA.
  • Gaucher G; Inversago Pharma, Montreal, Quebec, Canada.
  • Ravenelle F; Inversago Pharma, Montreal, Quebec, Canada.
  • Cinar R; Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
  • Xu X; Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA. Electronic address: xin.xu3@nih.gov.
Biomed Pharmacother ; 168: 115178, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37890204
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Hermanski-Pudlak Syndrome Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2023 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Hermanski-Pudlak Syndrome Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2023 Document type: Article Country of publication: