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A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study.
Jackson, Heather R; Zandstra, Judith; Menikou, Stephanie; Hamilton, Melissa Shea; McArdle, Andrew J; Fischer, Roman; Thorne, Adam M; Huang, Honglei; Tanck, Michael W; Jansen, Machiel H; De, Tisham; Agyeman, Philipp K A; Von Both, Ulrich; Carrol, Enitan D; Emonts, Marieke; Eleftheriou, Irini; Van der Flier, Michiel; Fink, Colin; Gloerich, Jolein; De Groot, Ronald; Moll, Henriette A; Pokorn, Marko; Pollard, Andrew J; Schlapbach, Luregn J; Tsolia, Maria N; Usuf, Effua; Wright, Victoria J; Yeung, Shunmay; Zavadska, Dace; Zenz, Werner; Coin, Lachlan J M; Casals-Pascual, Climent; Cunnington, Aubrey J; Martinon-Torres, Federico; Herberg, Jethro A; de Jonge, Marien I; Levin, Michael; Kuijpers, Taco W; Kaforou, Myrsini.
Affiliation
  • Jackson HR; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Zandstra J; Sanquin Research and Landsteiner Laboratory, Department of Immunopathology, Sanquin Blood Supply, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center
  • Menikou S; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Hamilton MS; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • McArdle AJ; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Fischer R; Discovery Proteomics Facility, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Thorne AM; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
  • Huang H; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Tanck MW; Department of Epidemiology and Data Science, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands.
  • Jansen MH; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands.
  • De T; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Agyeman PKA; Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Von Both U; Infectious Diseases, Department of Pediatrics, Dr von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.
  • Carrol ED; Department of Clinical Infection Microbiology and Immunology, University of Liverpool Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Emonts M; Paediatric Infectious Diseases and Immunology Department, Newcastle upon Tyne Hospitals Foundation Trust, Great North Children's Hospital, Newcastle upon Tyne, UK.
  • Eleftheriou I; Second Department of Paediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, Panagiotis & Aglaia, Kyriakou Children's Hospital, Athens, Greece.
  • Van der Flier M; Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands; Pediatric Infectious Diseases and Immunology Amalia Children's Hospital, Department of Laboratory Medicine, Radboud Institute of Molecular Life Sciences, Radboud UM
  • Fink C; Micropathology, University of Warwick, Warwick, UK.
  • Gloerich J; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute of Molecular Life Sciences, Radboud UMC, Nijmegen, Netherlands.
  • De Groot R; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute of Molecular Life Sciences, Radboud UMC, Nijmegen, Netherlands.
  • Moll HA; Department of Pediatrics, Erasmus MC, Rotterdam, Netherlands.
  • Pokorn M; Division of Paediatrics, University Medical Centre Ljubljana and Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
  • Pollard AJ; Oxford Vaccine Group Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Schlapbach LJ; Department of Intensive Care and Neonatology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Child Health Research Centre, The University of Queensland, Brisbane, NSW, Australia.
  • Tsolia MN; Second Department of Paediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, Panagiotis & Aglaia, Kyriakou Children's Hospital, Athens, Greece.
  • Usuf E; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, Gambia.
  • Wright VJ; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Yeung S; Clinical Research Department, Faculty of Infectious and Tropical Disease, London School of Hygiene & Tropical Medicine, London, UK.
  • Zavadska D; Children's Clinical University Hospital, Riga Stradins University, Rïga, Latvia.
  • Zenz W; University Clinic of Paediatrics and Adolescent Medicine, Department of General Paediatrics, Medical University Graz, Graz, Austria.
  • Coin LJM; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Casals-Pascual C; Department of Clinical Microbiology, CDB, Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain.
  • Cunnington AJ; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Martinon-Torres F; Translational Pediatrics and Infectious Diseases Section, Pediatrics Department, Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain; Genetics, Vaccines, Infectious Diseases, and Pediatrics research group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Univer
  • Herberg JA; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • de Jonge MI; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute of Molecular Life Sciences, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute of Molecular Life Sciences, Radboud UMC, Nijmegen, Netherlan
  • Levin M; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK.
  • Kuijpers TW; Sanquin Research and Landsteiner Laboratory, Department of Immunopathology, Sanquin Blood Supply, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center
  • Kaforou M; Section of Paediatric Infectious Disease, Faculty of Medicine, and Centre for Paediatrics and Child Health, Imperial College London, London, UK. Electronic address: m.kaforou@imperial.ac.uk.
Lancet Digit Health ; 5(11): e774-e785, 2023 11.
Article in En | MEDLINE | ID: mdl-37890901
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Virus Diseases Limits: Child / Humans Language: En Journal: Lancet Digit Health Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Virus Diseases Limits: Child / Humans Language: En Journal: Lancet Digit Health Year: 2023 Document type: Article Affiliation country: