Longitudinal investigation of aortic dissection in mice with computational fluid dynamics.
Comput Methods Biomech Biomed Engin
; : 1-14, 2023 Oct 28.
Article
in En
| MEDLINE
| ID: mdl-37897230
ABSTRACT
Predicting late adverse events in aortic dissections is challenging. One commonly observed risk factor is partial thrombosis of the false lumen. In this study we investigated false lumen thrombus progression over 7 days in four mice with angiotensin II-induced aortic dissection. We performed computational fluid dynamic simulations with subject-specific boundary conditions from velocity and pressure measurements. We investigated endothelial cell activation potential, mean velocity, thrombus formation potential, and other hemodynamic factors. Our findings support the hypothesis that flow stagnation is the predominant hemodynamic factor driving a large thrombus ratio in false lumina, particularly those with a single fenestration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Comput Methods Biomech Biomed Engin
Journal subject:
ENGENHARIA BIOMEDICA
/
FISIOLOGIA
Year:
2023
Document type:
Article
Affiliation country: