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Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
Thoma, Gebhard; Decoret, Odile; Vangrevelinghe, Eric; Trunzer, Markus; Decker, Andrea; Orjuela Leon, Anette; Beerli, Christian; Bruno, Sandro; Hauchard, Alice; Paulat, Guido; Zerwes, Hans-Guenter; Hacini-Rachinel, Feriel.
Affiliation
  • Thoma G; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Decoret O; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Vangrevelinghe E; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Trunzer M; PK Sciences, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Decker A; Chemical and Pharmaceutical Profiling, Global Drug Development, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Orjuela Leon A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Beerli C; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Bruno S; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Hauchard A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Paulat G; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Zerwes HG; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
  • Hacini-Rachinel F; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
J Med Chem ; 66(21): 15042-15053, 2023 11 09.
Article in En | MEDLINE | ID: mdl-37906573
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Janus Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Janus Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication: