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Revolutionizing Tuberculosis Treatment: Uncovering New Drugs and Breakthrough Inhibitors to Combat Drug-Resistant Mycobacterium tuberculosis.
Verma, Ankit; Naik, Bindu; Kumar, Vijay; Mishra, Sadhna; Choudhary, Megha; Khan, Javed Masood; Gupta, Arun Kumar; Pandey, Piyush; Rustagi, Sarvesh; Kakati, Barnali; Gupta, Sanjay.
Affiliation
  • Verma A; Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, Uttarakhand, India.
  • Naik B; Department of Food Science and Technology, Graphic Era Deemed to be University, Bell Road, Clement Town, Dehradun 248002, Uttarakhand, India.
  • Kumar V; Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, Uttarakhand, India.
  • Mishra S; Faculty of Agricultural Sciences, GLA University, Mathura 281406, UP, India.
  • Choudhary M; Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, Uttarakhand, India.
  • Khan JM; Department of Food Science and Nutrition, Faculty of Food and Agricultural Sciences, King Saud University, 2460, Riyadh 11451, Saudi Arabia.
  • Gupta AK; Department of Food Science and Technology, Graphic Era Deemed to be University, Bell Road, Clement Town, Dehradun 248002, Uttarakhand, India.
  • Pandey P; Department of Microbiology, Assam University, Silchur 788011, Assam, India.
  • Rustagi S; Department of Food Technology, UCALS, Uttaranchal University, Dehradun 248007, Uttarakhand, India.
  • Kakati B; Department of Microbiology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, U.K., India.
  • Gupta S; Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, Uttarakhand, India.
ACS Infect Dis ; 9(12): 2369-2385, 2023 Dec 08.
Article in En | MEDLINE | ID: mdl-37944023
ABSTRACT
Tuberculosis (TB) is a global health threat that causes significant mortality. This review explores chemotherapeutics that target essential processes in Mycobacterium tuberculosis, such as DNA replication, protein synthesis, cell wall formation, energy metabolism, and proteolysis. We emphasize the need for new drugs to treat drug-resistant strains and shorten the treatment duration. Emerging targets and promising inhibitors were identified by examining the intricate biology of TB. This review provides an overview of recent developments in the search for anti-TB drugs with a focus on newly validated targets and inhibitors. We aimed to contribute to efforts to combat TB and improve therapeutic outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Limits: Humans Language: En Journal: ACS Infect Dis Year: 2023 Document type: Article Affiliation country:
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Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Limits: Humans Language: En Journal: ACS Infect Dis Year: 2023 Document type: Article Affiliation country: