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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis.
Tamura, Ryutaro; Sabu, Yusuke; Mizuno, Tadahaya; Mizuno, Seiya; Nakano, Satoshi; Suzuki, Mitsuyoshi; Abukawa, Daiki; Kaji, Shunsaku; Azuma, Yoshihiro; Inui, Ayano; Okamoto, Tatsuya; Shimizu, Seiichi; Fukuda, Akinari; Sakamoto, Seisuke; Kasahara, Mureo; Takahashi, Satoru; Kusuhara, Hiroyuki; Zen, Yoh; Ando, Tomohiro; Hayashi, Hisamitsu.
Affiliation
  • Tamura R; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • Sabu Y; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • Mizuno T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • Mizuno S; Laboratory Animal Resource Center and Trans-Border Medical Research Center, University of Tsukuba, Ibaraki, Japan.
  • Nakano S; Department of Pediatrics, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Suzuki M; Department of Pediatrics, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Abukawa D; Department of Gastroenterology and Hepatology, Miyagi Children's Hospital, Miyagi, Japan.
  • Kaji S; Department of Pediatrics, Tsuyama-Chuo Hospital, Okayama, Japan.
  • Azuma Y; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Inui A; Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan.
  • Okamoto T; Department of Pediatric Surgery, Kyoto University Hospital, Kyoto, Japan.
  • Shimizu S; Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
  • Fukuda A; Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
  • Sakamoto S; Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
  • Kasahara M; Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
  • Takahashi S; Laboratory Animal Resource Center and Trans-Border Medical Research Center, University of Tsukuba, Ibaraki, Japan.
  • Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • Zen Y; Institute of Liver Studies, King's College Hospital & King's College London, London, UK.
  • Ando T; Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan.
  • Hayashi H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan. hayapi@mol.f.u-tokyo.ac.jp.
Nat Commun ; 14(1): 6763, 2023 Nov 21.
Article in En | MEDLINE | ID: mdl-37990006
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choline Deficiency / Fatty Liver / Gastrointestinal Diseases / Intestinal Diseases Limits: Animals / Child / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choline Deficiency / Fatty Liver / Gastrointestinal Diseases / Intestinal Diseases Limits: Animals / Child / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: