Role of ferroptosis in food-borne mycotoxin-induced toxicities.
Apoptosis
; 29(3-4): 267-276, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38001339
ABSTRACT
Contamination by toxic substances is a major global food safety issue, which poses a serious threat to human health. Mycotoxins are major class of food contaminants, mainly including aflatoxins (AFs), zearalenone (ZON), deoxynivalenol (DON), ochratoxin A (OTA), fumonisins (FBs) and patulin (PAT). Ferroptosis is a newly identified iron-dependent form of programmed or regulated cell death, which has been found to be involved in diverse pathological conditions. Recently, a growing body of evidence has shown that ferroptosis is implicated in the toxicities induced by certain types of food-borne mycotoxins, which provides novel mechanistic insights into mycotoxin-induced toxicities and paves the way for developing ferroptosis-based strategy to combat against toxicities of mycotoxins. In this review article, we summarize the key findings on the involvement of ferroptosis in mycotoxin-induced toxicities and propose issues that need to be addressed in future studies for better utilization of ferroptosis-based approach to manage the toxic effects of mycotoxin contamination.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trichothecenes
/
Zearalenone
/
Ferroptosis
/
Mycotoxins
Limits:
Humans
Language:
En
Journal:
Apoptosis
Year:
2024
Document type:
Article
Affiliation country: