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LORF9 of Marek's disease virus is involved in the early cytolytic replication of B lymphocytes and can act as a target for gene deletion vaccine development.
Zhu, Xiaojing; Wang, Lele; Gong, Lele; Zhai, Yunyun; Wang, Rui; Jin, Jiaxin; Lu, Wenlong; Zhao, Xuyang; Liao, Yifei; Zhang, Gaiping; Zhuang, Guoqing; Sun, Aijun.
Affiliation
  • Zhu X; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Wang L; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
  • Gong L; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Zhai Y; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
  • Wang R; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Jin J; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
  • Lu W; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Zhao X; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
  • Liao Y; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Zhang G; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
  • Zhuang G; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Sun A; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China.
J Virol ; 97(12): e0157423, 2023 Dec 21.
Article in En | MEDLINE | ID: mdl-38014947
ABSTRACT
IMPORTANCE Marek's disease virus (MDV) is a highly infectious and oncogenic virus that can induce severe T cell lymphomas in chickens. MDV encodes more than 100 genes, most of which have unknown functions. This work indicated that the LORF9 gene is necessary for MDV early cytolytic replication in B lymphocytes. In addition, we have found that the LORF9 deletion mutant has a comparative immunological protective effect with CVI988/Rispens vaccine strain against very virulent MDV challenge. This is a significant discovery that LORF9 can be exploited as a possible target for the development of an MDV gene deletion vaccine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poultry Diseases / Marek Disease / Herpesvirus 2, Gallid / Marek Disease Vaccines Limits: Animals Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poultry Diseases / Marek Disease / Herpesvirus 2, Gallid / Marek Disease Vaccines Limits: Animals Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: