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Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold.
Thalén, Niklas Berndt; Barzadd, Mona Moradi; Lundqvist, Magnus; Rodhe, Johanna; Andersson, Monica; Bidkhori, Gholamreza; Possner, Dominik; Su, Chao; Nilsson, Joakim; Eisenhut, Peter; Malm, Magdalena; Karlsson, Alice; Vestin, Jeanette; Forsberg, Johan; Nordling, Erik; Mardinoglu, Adil; Volk, Anna-Luisa; Sandegren, Anna; Rockberg, Johan.
Affiliation
  • Thalén NB; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Barzadd MM; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Lundqvist M; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Rodhe J; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Andersson M; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Bidkhori G; Science for Life Laboratory, KTH - Royal Institute of Technology, Solna, 171 65, Sweden; AIVIVO Ltd. Unit 25, Bio-innovation centre, Cambridge Science park, Cambridge, UK.
  • Possner D; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Su C; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Nilsson J; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Eisenhut P; ACIB - Austrian Centre of Industrial Biotechnology, Krenngasse 37, 8010 Graz, Austria; BOKU - University of Natural Resources and Life Sciences, Department of Biotechnology, Vienna, 1190, Austria.
  • Malm M; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Karlsson A; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Vestin J; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Forsberg J; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Nordling E; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Mardinoglu A; Science for Life Laboratory, KTH - Royal Institute of Technology, Solna, 171 65, Sweden.
  • Volk AL; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden.
  • Sandegren A; SOBI AB, Tomtebodavägen 23A, Stockholm, Sweden.
  • Rockberg J; Dept. of Protein science, KTH - Royal Institute of Technology, Stockholm, SE-106 91, Sweden. Electronic address: johanr@biotech.kth.se.
Metab Eng ; 81: 157-166, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38081506
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfatases Limits: Humans Language: En Journal: Metab Eng Journal subject: ENGENHARIA BIOMEDICA / METABOLISMO Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfatases Limits: Humans Language: En Journal: Metab Eng Journal subject: ENGENHARIA BIOMEDICA / METABOLISMO Year: 2024 Document type: Article Affiliation country: Country of publication: