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Live-virus serum neutralization after bivalent SARS-CoV-2 mRNA vaccination in hemodialysis patients.
Benning, Louise; Bartenschlager, Marie; Kim, Heeyoung; Kälble, Florian; Nusshag, Christian; Buylaert, Mirabel; Reichel, Paula; Schaier, Matthias; Morath, Christian; Zeier, Martin; Schnitzler, Paul; Bartenschlager, Ralf; Speer, Claudius.
Affiliation
  • Benning L; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Bartenschlager M; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
  • Kim H; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
  • Kälble F; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Nusshag C; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Buylaert M; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Reichel P; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Schaier M; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Morath C; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Zeier M; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
  • Schnitzler P; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
  • Bartenschlager R; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
  • Speer C; German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany.
J Med Virol ; 95(12): e29303, 2023 12.
Article in En | MEDLINE | ID: mdl-38082556
ABSTRACT
The development of bivalent booster vaccines addresses the ongoing evolution of the emerging B.1.1.529 (omicron) variant subtypes that are known to escape vaccine-induced neutralizing antibody response. Little is known about the immunogenicity and reactogenicity of bivalent mRNA vaccines in hemodialysis patients with impaired vaccine response. In this prospective, observational cohort study, we analyzed SARS-CoV-2 anti-S1 IgG, surrogate neutralizing antibodies (SNA), and live-virus neutralization against the SARS-CoV-2 wildtype and the BA.5 variant in 42 hemodialysis patients with and without prior SARS-CoV-2 infection before and after an additional fifth bivalent vaccine dose. Anti-S1 IgG and SNA were significantly higher in hemodialysis patients with prior infection than in patients without infection (p < 0.001 and p < 0.01, respectively). In patients without prior infection, both antibody levels increased, and live-virus neutralizing antibodies against the wildtype and the BA.5 variant were correspondingly significantly higher after bivalent booster vaccination (p < 0.001 for both). Conversely, in patients with prior infection, anti-S1 IgG and SNA did not alter significantly, and bivalent booster vaccination did not induce additional humoral immune response against the SARS-CoV-2 wildtype and the BA.5 variant. Thus, bivalent mRNA vaccines might increase humoral responses in hemodialysis patients without prior infection. Larger clinical trials are needed to help guide vaccination strategies in these immunocompromised individuals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country:
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