Animal granulins: In the GRN scheme of things.
Dev Comp Immunol
; 152: 105115, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38101714
ABSTRACT
Granulins are conserved in nearly all metazoans, with an intriguing loss in insects. These pleiotropic peptides are involved in numerous physiological and pathological processes yet have been overwhelmingly examined in mammalian systems. While work in other animal models has been informative, a richer understanding of the proteins should be obtained by integrating knowledge from all available contexts. The main bodies of work described here include 1) the structure-function relationships of progranulin and its cleavage products, 2) the role of expanded granulin gene families and different isoforms in fish immunology, 3) the release of granulin peptides to promote host angiogenesis by parasitic worms, 4) a diversity of molluscan uses for granulins, including immune activation in intermediate hosts to trematodes, 5) knowledge gained on lysosomal functions from C. elegans and the stress-related activities of granulins. We provide an overview of functional reports across the Metazoa to inform much-needed future research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caenorhabditis elegans
/
Mammals
Limits:
Animals
Language:
En
Journal:
Dev Comp Immunol
/
Dev. comp. inmunol
/
Developmental and comparative immunology
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: