Clinical predictive value of renalase in post-ERCP pancreatitis.
Gastrointest Endosc
; 99(5): 822-825.e1, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38103747
ABSTRACT
BACKGROUND AND AIMS:
Plasma levels of renalase decrease in acute experimental pancreatitis. We aimed to determine if decreases in plasma renalase levels after ERCP predict the occurrence of post-ERCP pancreatitis (PEP).METHODS:
In this prospective cohort study conducted at a tertiary hospital, plasma renalase was determined before ERCP (baseline) and at 30 and 60 minutes after ERCP. Native renalase levels, acidified renalase, and native-to-acidified renalase proportions were analyzed over time using a longitudinal regression model.RESULTS:
Among 273 patients, 31 developed PEP. Only 1 PEP patient had a baseline native renalase >6.0 µg/mL, whereas 38 of 242 without PEP had a native renalase > 6.0 µg/mL, indicating a sensitivity of 97% (30/31) and specificity of 16% (38/242) in predicting PEP. Longitudinal models did not show differences over time between groups.CONCLUSIONS:
Baseline native renalase levels are very sensitive for predicting PEP. Further studies are needed to determine the potential clinical role of renalase in predicting and preventing PEP.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Gastrointest Endosc
/
Gastrointest. endosc
/
Gastrointestinal endoscopy
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: