The cortical high-flow sign of oligodendroglioma, IDH-mutant and 1p/19q-codeleted: comparison between arterial spin labeling and dynamic susceptibility contrast methods.
Neuroradiology
; 66(2): 187-192, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38127124
ABSTRACT
PURPOSE:
The cortical high-flow sign with the non-enhancing area was reportedly found to be more frequent with oligodendroglioma, IDH-mutant and 1p/19q codeleted (ODG IDHm-codel) than with IDH-wildtype or astrocytoma, IDH-mutant on arterial spin labeling (ASL) in diffuse gliomas. This study aimed to compare the identification rate of the cortical high-flow sign on ASL in patients with ODG IDHm-codel to that on dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI).METHODS:
Participants consisted of 32 adult ODG IDHm-codel patients with pathologically confirmed. Subtraction images were generated from paired control and label images on ASL. For DSC, dynamic T2*-weighted perfusion weighted images were obtained after pre-bolus of gadolinium-based contrast agent. Regional cerebral blood flow/volume maps were generated based on the concentration-time curve and arterial input function. Tumor-affecting cortices without contrast enhancement on conventional MR imaging were targeted. The identification rate of the cortical high-flow sign was compared between ASL and DSC using the Pearson's Chi-Square test.RESULTS:
Frequency of the cortical high-flow sign was significantly higher on ASL (18/32, 56.3%; p < 0.001) than on DSC (5/32, 15.6%). All cases with the positive cortical high-flow sign on DSC were identified on ASL.CONCLUSION:
ASL effectively identifies the cortical high-flow sign in ODG IDHm-codel, surpassing DSC in identification rates.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligodendroglioma
/
Brain Neoplasms
/
Glioma
Limits:
Adult
/
Humans
Language:
En
Journal:
Neuroradiology
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: