CD1a and skin T cells: a pathway for therapeutic intervention.
Clin Exp Dermatol
; 49(5): 450-458, 2024 Apr 23.
Article
in En
| MEDLINE
| ID: mdl-38173286
ABSTRACT
The CD1 and MR1 protein families present lipid antigens and small molecules to T cells, complementing well-studied major histocompatibility complex-peptide mechanisms. The CD1a subtype is highly and continuously expressed within the skin, most notably on Langerhans cells, and has been demonstrated to present self and foreign lipids to T cells, highlighting its cutaneous sentinel role. Alteration of CD1a-dependent T-cell responses has recently been discovered to contribute to the pathogenesis of several inflammatory skin diseases. In this review, we overview the structure and role of CD1a and outline the current evidence implicating CD1a in the development of psoriasis, atopic dermatitis and allergic contact dermatitis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases
/
T-Lymphocytes
/
Antigens, CD1
Limits:
Humans
Language:
En
Journal:
Clin Exp Dermatol
Year:
2024
Document type:
Article
Affiliation country: