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mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis.
Matias, Jaqueline; Cui, Yingjun; Lynn, Geoffrey E; DePonte, Kathleen; Mesquita, Emily; Muramatsu, Hiromi; Alameh, Mohamad G; Dwivedi, Garima; Tam, Ying K; Pardi, Norbert; Weissman, Drew; Fikrig, Erol.
Affiliation
  • Matias J; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA. jaqmatias@hotmail.com.
  • Cui Y; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Lynn GE; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • DePonte K; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Mesquita E; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Alameh MG; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Dwivedi G; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Tam YK; Acuitas Therapeutics, Vancouver, BC, V6T 1Z3, Canada.
  • Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Weissman D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Fikrig E; Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA. erol.fikrig@yale.edu.
Sci Rep ; 14(1): 496, 2024 01 04.
Article in En | MEDLINE | ID: mdl-38177212
ABSTRACT
19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore, has the potential to interrupt the tick reproductive cycle, without triggering some of the other effects associated with acquired tick resistance. This may lead to the development of new strategies to reduce I. scapularis populations in endemic areas.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ixodes Limits: Animals Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ixodes Limits: Animals Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: