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Platelet-to-albumin ratio is a potential biomarker for predicting diabetic nephropathy in patients with type 2 diabetes.
Cao, Shi-Lu; Zhang, Guo-Qing; Li, Jing; Bao, Li; Lan, Xiao-Mei; Jin, Quan-Peng; Luo, Hong-Yan; E, Jing; Li, Bo; Ma, Danna; Bao, Xi; Zheng, Ya-Li.
Affiliation
  • Cao SL; Department of Nephrology, Ningxia Medical University Affifiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Zhang GQ; The Third Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Li J; Department of Nephrology, Ningxia Medical University Affifiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Bao L; The Third Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Lan XM; Department of Pathology, Ningxia Medical University Affiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Jin QP; Department of Nephrology, Ningxia Medical University Affifiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Luo HY; The Third Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • E J; Department of Geriatrics, Ningxia Medical University Affiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Li B; Dialysis Department of Nephrology Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710000, China.
  • Ma D; Department of Endocrinology, Ningxia Medical University Affiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Bao X; Department of Nephrology, Ningxia Medical University Affifiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China.
  • Zheng YL; The Third Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Biomark Med ; 17(20): 841-848, 2023 10.
Article in En | MEDLINE | ID: mdl-38180339
ABSTRACT

Aim:

To evaluate whether platelet-to-albumin ratio (PAR) can predict diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). Materials &

methods:

A total of 140 patients with T2DM and 40 healthy individuals were enrolled retrospectively. T2DM patients were divided into three groups based on the urinary albumin-to-creatinine ratio, PAR was compared and receiver operating characteristic curve was constructed to evaluate the predictive value of PAR in DN in T2DM.

Results:

There was a significant increase of PAR in DN among T2DM patients and PAR was positively correlated with serum creatinine, retinol-conjugated protein and ß2-microglobulin. Moreover, PAR was a risk factor for DN in T2DM patients, which predicted DN in T2DM with high sensitivity and specificity.

Conclusion:

PAR can be a potential candidate to predict DN in T2DM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Diabetic Nephropathies Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Diabetic Nephropathies Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2023 Document type: Article Affiliation country: Country of publication: