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Clinical characteristics and healthcare resource utilization in patients with chronic obstructive pulmonary disease in Hong Kong.
Ko, Fanny Wai San; Xu, Xiaomeng; Chau, Clementine; Navarro, Aldo; Hui, David Shu Cheong; Milea, Dominique.
Affiliation
  • Ko FWS; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address: fannyko@cuhk.edu.hk.
  • Xu X; GSK, Greater China and Intercontinental, Singapore.
  • Chau C; GSK, Hong Kong.
  • Navarro A; GSK, Greater China and Intercontinental, Singapore.
  • Hui DSC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
  • Milea D; GSK, Greater China and Intercontinental, Singapore.
Respir Med ; 222: 107516, 2024 02.
Article in En | MEDLINE | ID: mdl-38184091
ABSTRACT

OBJECTIVES:

Chronic obstructive pulmonary disease (COPD) is a significant cause of mortality, with its prevalence projected to rise in Asia. The primary objective of this study was to describe clinical characteristics, maintenance treatment, and healthcare resource utilization (HCRU) among patients with COPD in Hong Kong. Secondary objectives were to assess patient demographics and clinical characteristics by eosinophil (EOS) levels, and compare the demographics, clinical characteristics, and treatment patterns of patients on multiple-inhaler triple therapy (MITT).

METHODS:

This study analyzed a cohort of patients with COPD who had entered a previously initiated prospective cohort study involving patients with COPD and/or asthma at the Prince of Wales Hospital between 2017 and 2019.

RESULTS:

Patients with COPD were enrolled (N = 220, mean age 74.3 years, 97 % male). Twelve months prior to baseline assessment, 66 % of patients were on MITT, 17 % on long-acting muscarinic antagonists (LAMAs)/long-acting beta-agonists (LABAs), and 7 % on inhaled corticosteroids (ICS)/LABA. Compared with ICS/LABA or LAMA/LABA, more patients on MITT experienced ≥1 exacerbation (26.7 %, 10.5 %, 39.7 %, respectively). Patients on MITT also had a higher mean (SD) COPD Assessment Test score (9.4 [5.9]) and modified Medical Research Council Dyspnea Scale score (1.7 [0.7]) and incurred the most COPD-related and total HCRU costs. Compared with patients with EOS ≤300 cells/µL, those with EOS >300 cells/µL had a higher number of exacerbations.

CONCLUSIONS:

Patients with COPD in Hong Kong treated with MITT presented more severe disease profiles and incurred higher costs. These data can be used for decision making in patients with moderate-to-severe COPD in Hong Kong.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Adrenergic beta-2 Receptor Agonists Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Implementation_research Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Respir Med Year: 2024 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Adrenergic beta-2 Receptor Agonists Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Implementation_research Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Respir Med Year: 2024 Document type: Article Country of publication: