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A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation.
Li, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; Reimann, Brigitte; Marques, Irene; Silver, Matt J; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C; Metayer, Catherine; Morimoto, Libby; Stein, Dan J; Zar, Heather J; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Kajantie, Eero; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent W V; Bernstein, Robin M; Prentice, Andrew M; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria C; Munthe-Kaas, Monica Cheng; Page, Christian M; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina.
Affiliation
  • Li S; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
  • Spitz N; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
  • Ghantous A; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
  • Abrishamcar S; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Reimann B; Centre for Environmental Sciences, UHasselt, Agoralaan, Building D, 3590, Diepenbeek, Belgium.
  • Marques I; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Silver MJ; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Aguilar-Lacasaña S; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
  • Kitaba N; ISGlobal, Institute for Global Health, Barcelona, Spain.
  • Rezwan FI; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Röder S; CIBER Epidemiología y Salud Pública, Madrid, Spain.
  • Sirignano L; Human Development and Health, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.
  • Tuhkanen J; Human Development and Health, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.
  • Mancano G; Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion, SY23 3DB, UK.
  • Sharp GC; Department of Environmental Immunology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany.
  • Metayer C; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Morimoto L; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  • Stein DJ; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Zar HJ; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Alfano R; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
  • Nawrot T; School of Public Health, University of California Berkeley, Berkeley, California, USA.
  • Wang C; School of Public Health, University of California Berkeley, Berkeley, California, USA.
  • Kajantie E; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Rondebosch, South Africa.
  • Keikkala E; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Rondebosch, South Africa.
  • Mustaniemi S; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
  • Ronkainen J; Centre for Environmental Sciences, UHasselt, Agoralaan, Building D, 3590, Diepenbeek, Belgium.
  • Sebert S; Centre for Environmental Sciences, UHasselt, Agoralaan, Building D, 3590, Diepenbeek, Belgium.
  • Silva W; Centre for Environmental Sciences, UHasselt, Agoralaan, Building D, 3590, Diepenbeek, Belgium.
  • Vääräsmäki M; Clinical Medicine Research Unit, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, Oulu, Finland.
  • Jaddoe VWV; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Bernstein RM; Pediatric Research Centre, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Prentice AM; Clinical Medicine Research Unit, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, Oulu, Finland.
  • Cosin-Tomas M; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Oulu, Finland.
  • Dwyer T; Clinical Medicine Research Unit, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, Oulu, Finland.
  • Håberg SE; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Oulu, Finland.
  • Herceg Z; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Magnus MC; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Munthe-Kaas MC; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Page CM; Clinical Medicine Research Unit, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, Oulu, Finland.
  • Völker M; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Oulu, Finland.
  • Gilles M; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Send T; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Witt S; Department of Anthropology and Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.
  • Zillich L; MRC Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
  • Gagliardi L; ISGlobal, Institute for Global Health, Barcelona, Spain.
  • Richiardi L; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Czamara D; CIBER Epidemiología y Salud Pública, Madrid, Spain.
  • Räikkönen K; Nuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Chatzi L; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Vafeiadi M; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Commun Biol ; 7(1): 66, 2024 01 09.
Article in En | MEDLINE | ID: mdl-38195839
ABSTRACT
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Birth Order / DNA Methylation Type of study: Systematic_reviews Limits: Child / Female / Humans / Newborn / Pregnancy Language: En Journal: Commun Biol Year: 2024 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Birth Order / DNA Methylation Type of study: Systematic_reviews Limits: Child / Female / Humans / Newborn / Pregnancy Language: En Journal: Commun Biol Year: 2024 Document type: Article Affiliation country: