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Staphylococcus argenteus bacteremia in the Republic of Korea.
Lee, Minkyeong; Choi, Yunsang; Choi, Seong Jin; Moon, Song Mi; Kim, Eu Suk; Kim, Hong Bin; Ahn, Soyeon; Lee, Hyunju; Kim, Jaeeun; Shin, Dong Woo; Yeom, Jinki; Park, Jeong Su; Song, Kyoung-Ho.
Affiliation
  • Lee M; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Choi Y; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Choi SJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Moon SM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Kim ES; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Kim HB; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Ahn S; Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Lee H; Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Kim J; Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Republic of Korea.
  • Shin DW; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Yeom J; Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Republic of Korea.
  • Park JS; Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
  • Song K-H; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Microbiol Spectr ; 12(2): e0279823, 2024 Feb 06.
Article in En | MEDLINE | ID: mdl-38197655
ABSTRACT
In 2015, Staphylococcus argenteus and Staphylococcus schweitzeri were proposed as new species, distinct from Staphylococcus aureus and collectively referred to as the S. aureus complex. However, no clinical reports of these new species exist in Korea. Upon the application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for all bloodstream isolates since September 2022, S. argenteus was identified in one patient. Therefore, we aimed to search for new species among the archives of the S. aureus bacteremia cohort and describe their clinical and microbiological characteristics. Among the 691 archived S. aureus isolates between 2012 and 2018, one was identified as S. argenteus via MALDI-TOF MS. Both S. argenteus isolates (one in 2022) were obtained from patients with extensive pneumonia accompanied by bacteremia and both cases had fatal outcomes. They harbored multiple virulence genes (clfA, clfB, fnbpA, sdrC, sdrD, sdrE, bbp, cna, see, seg, sei, blaZ, fnbpB, and map) but did not harbor mecA and pvl. No matched sequence type (ST) was found in either isolate, and both S. argenteus isolates were closely related to ST1594, ST1593, ST1793, and ST1303, which belonged to S. argenteus. S. argenteus accounted for <1% of the S. aureus complex but had clinical characteristics similar to S. aureus. Therefore, clinicians should be aware of these factors to avoid misidentifying these strains as coagulase-negative staphylococci, and appropriate reporting is required to minimize confusion.IMPORTANCEStaphylococcus argenteus, a member of Staphylococcus aureus complex, has been reported as an important pathogen that causes clinically invasive infections in humans similar to S. aureus. Clinical isolates of S. argenteus have been reported across the world, showing a large geographical difference in prevalence and genomic profile. However, there have been no clinical reports regarding this new species in Korea. This is the first report to investigate the clinical and genetic characteristics of S. argenteus identified in patients with bacteremia, and the proportion of S. argenteus bacteremia among S. aureus bacteremia cohort in Korea.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus / Bacteremia Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus / Bacteremia Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Country of publication: