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Essential-Oils-Loaded Biopolymeric Nanoparticles as Strategies for Microbial and Biofilm Control: A Current Status.
Romero-Montero, Alejandra; Melgoza-Ramírez, Luis Javier; Ruíz-Aguirre, Jesús Augusto; Chávez-Santoscoy, Alejandra; Magaña, Jonathan Javier; Cortés, Hernán; Leyva-Gómez, Gerardo; Del Prado-Audelo, María Luisa.
Affiliation
  • Romero-Montero A; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
  • Melgoza-Ramírez LJ; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Mexico City 14380, Mexico.
  • Ruíz-Aguirre JA; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Mexico City 14380, Mexico.
  • Chávez-Santoscoy A; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Campus Monterrey, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64849, Mexico.
  • Magaña JJ; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Mexico City 14380, Mexico.
  • Cortés H; Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico.
  • Leyva-Gómez G; Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico.
  • Del Prado-Audelo ML; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Int J Mol Sci ; 25(1)2023 Dec 20.
Article in En | MEDLINE | ID: mdl-38203252
ABSTRACT
The emergence of bacterial strains displaying resistance to the currently available antibiotics is a critical global concern. These resilient bacteria can form biofilms that play a pivotal role in the failure of bacterial infection treatments as antibiotics struggle to penetrate all biofilm regions. Consequently, eradicating bacteria residing within biofilms becomes considerably more challenging than their planktonic counterparts, leading to persistent and chronic infections. Among various approaches explored, essential oils loaded in nanoparticles based on biopolymers have emerged, promising strategies that enhance bioavailability and biological activities, minimize side effects, and control release through regulated pharmacokinetics. Different available reviews analyze nanosystems and essential oils; however, usually, their main goal is the analysis of their antimicrobial properties, and progress in biofilm combat is rarely discussed, or it is not the primary objective. This review aims to provide a global vision of biofilm conformation and describes mechanisms of action attributed to each EO. Furthermore, we present a comprehensive overview of the latest developments in biopolymeric nanoparticles research, especially in chitosan- and zein-based nanosystems, targeting multidrug-resistant bacteria in both their sessile and biofilm forms, which will help to design precise strategies for combating biofilms.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oils, Volatile / Nanoparticles Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oils, Volatile / Nanoparticles Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: