Microparticulated Polygonatum sibiricum polysaccharide shows potent vaccine adjuvant effect.
Int J Pharm
; 652: 123802, 2024 Mar 05.
Article
in En
| MEDLINE
| ID: mdl-38218508
ABSTRACT
Adjuvants are necessary for protein vaccines and have been used for nearly 100 years. However, developing safe and effective adjuvants is still urgently needed. Polysaccharides isolated from traditional Chinese medicine are considered novel vaccine adjuvant sources. This study aimed to investigate the adjuvant activity and immune-enhancing mechanisms of the microparticulated Polygonatum sibiricum polysaccharide (MP-PSP) modified by calcium carbonate. PSP demonstrated adjuvant activity, and MP-PSP further showed a higher humoral response compared to PSP. Subsequently, MP-PSP was elucidated to improving the immunity by slowing the rate of antigen release and activating dendritic cells along with interleukin-6 secretion through toll-like receptor 4 signaling, followed by T follicular helper cell and B cell interactions. Moreover, MP-PSP had a good safety profile in vaccinated mice. Thus, MP-PSP may be a promising vaccine adjuvant and warrants further investigation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polygonatum
/
Adjuvants, Vaccine
Limits:
Animals
Language:
En
Journal:
Int J Pharm
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: