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Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients.
Medina Néri, Ane Karoline; Silva, Ricardo Pereira; Meneses, Gdayllon Cavalcante; Costa Martins, Alice Maria; Portela Lima, Ana Ofélia; Callou Filho, Cesário Rui; Cavalcante Vidal, Francisco Daniel; de Oliveira Lima, Jeruza Mara; Rocha, Eduardo Arrais; da Silva Júnior, Geraldo Bezerra.
Affiliation
  • Medina Néri AK; University of Fortaleza, Health Sciences Center, Postgraduate Program in Collective Health, Fortaleza, 60811-905, Brazil.
  • Silva RP; Federal University of Ceará, Walter Cantídio Teaching Hospital, Cardiology Service, Fortaleza, 60430-372, Brazil.
  • Meneses GC; Federal University of Ceará, Federal University of Ceará, Medical Sciences Post-Graduate Program, Fortaleza, 60430-140, Brazil.
  • Costa Martins AM; Federal University of Ceará, Clinical and Toxicological Analysis Department, School of Pharmacy, Fortaleza, 60430-160, Brazil.
  • Portela Lima AO; University of Fortaleza, Health Sciences Center, Postgraduate Program in Collective Health, Fortaleza, 60811-905, Brazil.
  • Callou Filho CR; University of Fortaleza, Health Sciences Center, Postgraduate Program in Collective Health, Fortaleza, 60811-905, Brazil.
  • Cavalcante Vidal FD; Federal University of Ceará, Walter Cantídio Teaching Hospital, Cardiology Service, Fortaleza, 60430-372, Brazil.
  • de Oliveira Lima JM; Federal University of Ceará, Walter Cantídio Teaching Hospital, Cardiology Service, Fortaleza, 60430-372, Brazil.
  • Rocha EA; Federal University of Ceará, Walter Cantídio Teaching Hospital, Cardiology Service, Fortaleza, 60430-372, Brazil.
  • da Silva Júnior GB; University of Fortaleza, Health Sciences Center, Postgraduate Program in Collective Health, Fortaleza, 60811-905, Brazil.
Biomark Med ; 17(22): 935-946, 2023 11.
Article in En | MEDLINE | ID: mdl-38230971
ABSTRACT

Background:

Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics.

Aim:

To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics.

Methods:

Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics.

Results:

Higher VCAM-1 levels were associated with higher low-density lipoprotein cholesterol and non-high-density lipoprotein (HDL) cholesterol levels (in the group with inadequate glycohemoglobin A1c [HbA1c] levels), with higher glycemic levels (in the group with inadequate HDL cholesterol levels) and with lower HDL cholesterol levels (both groups). VCAM-1 was independently associated with not achieving adequate HbA1c levels.

Conclusion:

In uncontrolled diabetics, VCAM-1 was independently associated with having inadequate HbA1c levels, suggesting they may already have endothelial damage.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2023 Document type: Article Affiliation country: Country of publication: