Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression.
Cell Commun Signal
; 22(1): 49, 2024 01 17.
Article
in En
| MEDLINE
| ID: mdl-38233930
ABSTRACT
N4-acetylcytidine (ac4C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is significantly associated with various human diseases, especially cancer, and its formation depends on the catalytic activity of N-acetyltransferase 10 (NAT10), the only known protein that produces ac4C. This review discusses the detection techniques and regulatory mechanisms of ac4C and summarizes ac4C correlation with tumor occurrence, development, prognosis, and drug therapy. It also comments on a new biomarker for early tumor diagnosis and prognosis prediction and a new target for tumor therapy. Video Abstract.
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Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cell Commun Signal
Year:
2024
Document type:
Article
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