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Thioglucose-derived tetrasulfide, a unique polysulfide model compound.
Lindahl, Stephen; Shieh, Meg; Zhang, Tianli; Guo, Chunyu; Robinson, Jerome R; Sawa, Tomohiro; Xian, Ming.
Affiliation
  • Lindahl S; Department of Chemistry, Brown University, Providence, RI, 02912, USA.
  • Shieh M; Department of Chemistry, Brown University, Providence, RI, 02912, USA.
  • Zhang T; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.
  • Guo C; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.
  • Robinson JR; Department of Chemistry, Brown University, Providence, RI, 02912, USA.
  • Sawa T; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan. Electronic address: sawat@kumamoto-u.ac.jp.
  • Xian M; Department of Chemistry, Brown University, Providence, RI, 02912, USA. Electronic address: ming_xian@brown.edu.
Redox Biol ; 70: 103045, 2024 04.
Article in En | MEDLINE | ID: mdl-38245971
ABSTRACT
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, the compounds that are suitable for biological investigations are limited to cysteine- and glutathione-derived polysulfides. In this work, we report the preparation and evaluation of a novel polysulfide derived from thioglucose, which represents the first carbohydrate-based polysulfide. This compound, thioglucose tetrasulfide (TGS4), showed excellent stability and water solubility. H2S and persulfide production from TGS4, as well as its associated antioxidative property were also demonstrated. Additionally, TGS4 was demonstrated to significantly induce cellular sulfane sulfur level increase, in particular for the formation of hydropersulfides/trisulfides. These results suggest that TGS4 is a useful tool for polysulfide research.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydrogen Sulfide Language: En Journal: Redox Biol Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydrogen Sulfide Language: En Journal: Redox Biol Year: 2024 Document type: Article Affiliation country: Country of publication: