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Single-molecule detection assisted by the target-triggered signal amplification strategy for ultrasensitive quantitative analysis of intracellular telomerase activity.
Jiang, Chengfang; Wang, Qi; Geng, Jing; Li, Mengmeng; Zhang, Yuqi; Shi, Xinli; Zhang, Yan; Song, Xinyue; Zhang, Shusheng.
Affiliation
  • Jiang C; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Wang Q; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Geng J; Linyi Mental Health Center, Linyi City, Shandong Province, P.R. China. songxinyue428@163.com.
  • Li M; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Zhang Y; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Shi X; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Zhang Y; College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
  • Song X; Linyi Mental Health Center, Linyi City, Shandong Province, P.R. China. songxinyue428@163.com.
  • Zhang S; Linyi Mental Health Center, Linyi City, Shandong Province, P.R. China. songxinyue428@163.com.
Chem Commun (Camb) ; 60(14): 1912-1915, 2024 Feb 13.
Article in En | MEDLINE | ID: mdl-38259117
ABSTRACT
We developed a multiplex single-molecule quantitative assay of intracellular telomerase that used target-triggered signal amplification to enhance sensitivity, substrate reaction to increase signal stability, and quantum dots to enhance signal-to-noise ratio, obtaining an LOD of 5 × 10-14 IU for intracellular telomerase and LOD of 3 cells for multiple cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Telomerase / Quantum Dots Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Telomerase / Quantum Dots Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article