A case of exacerbated encephalopathy with stroke-like episodes and lactic acidosis triggered by metformin in a patient with MELAS.
Neurol Sci
; 45(5): 2337-2339, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38265537
ABSTRACT
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited multisystemic disorder caused by mutations in mitochondrial DNA that result in cellular energy deficiency. MELAS affects the most metabolically active organs, including the brain, skeletal muscles, cochlea, retina, heart, kidneys, and pancreas. As a result, about 85% of carriers of m.3243A > G, the most common mutation in MELAS, develop diabetes by the age of 70. Although metformin is the most widely prescribed drug for diabetes, its usefulness in mitochondrial dysfunction remains controversial. Here, we present the case of a 32-year-old Korean patient diagnosed with MELAS who presented with exacerbated stroke-like episodes and lactic acidosis triggered by metformin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acidosis, Lactic
/
MELAS Syndrome
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Stroke
/
Metformin
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country: