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Impact of maternal depression on malnutrition treatment outcomes in older children with sickle cell anemia.
Ritter, Claire; Abdullahi, Shehu U; Gambo, Safiya; Murtala, Hassan Adam; Kabir, Halima; Shamsu, Khadija A; Gwarzo, Garba; Banaei, Yasmin; Acra, Sari A; Stallings, Virginia A; Rodeghier, Mark; DeBaun, Michael R; Klein, Lauren J.
Affiliation
  • Ritter C; Meharry Medical College, Nashville, TN, USA.
  • Abdullahi SU; Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Gambo S; Department of Pediatrics, Murtala Mohammed Specialist Hospital, Kano, Nigeria.
  • Murtala HA; Department of Pediatrics, Murtala Mohammed Specialist Hospital, Kano, Nigeria.
  • Kabir H; Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Shamsu KA; Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Gwarzo G; Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Banaei Y; Yasmin Banaei MD LLC, Washington, DC, USA.
  • Acra SA; Department of Pediatrics, D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
  • Stallings VA; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
  • Rodeghier M; Rodeghier Consultants, Chicago, IL, USA.
  • DeBaun MR; Department of Pediatrics, Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Klein LJ; Vanderbilt Institute for Global Health, Nashville, TN, USA.
BMC Nutr ; 10(1): 18, 2024 Jan 24.
Article in En | MEDLINE | ID: mdl-38268013
ABSTRACT

BACKGROUND:

Malnutrition and sickle cell anemia (SCA) result in high childhood mortality rates. Although maternal depression is an established risk factor for malnutrition in younger children, little is known about its impact on treatment response in children with malnutrition. We aimed to determine the relationship, if any, between maternal depression scores and malnutrition treatment outcomes in older children with SCA.

METHODS:

We conducted a planned ancillary study to our randomized controlled feasibility trial for managing severe acute malnutrition in children aged 5-12 with SCA in northern Nigeria (NCT03634488). Mothers of participants completed a depression screen using the Patient Health Questionnaire (PHQ-9).We used a multivariable linear regression model to describe the relationship between the baseline maternal PHQ-9 score and the trial participant's final body mass index (BMI) z-score.

RESULTS:

Out of 108 mother-child dyads, 101 with maternal baseline PHQ-9 scores were eligible for inclusion in this analysis. At baseline, 25.7% of mothers (26 of 101) screened positive for at least mild depression (PHQ-9 score of 5 or above). The baseline maternal PHQ-9 score was negatively associated with the child's BMI z-score after 12 weeks of malnutrition treatment (ß=-0.045, p = 0.041).

CONCLUSIONS:

Maternal depressive symptoms has an impact on malnutrition treatment outcomes. Treatment of malnutrition in older children with sickle cell anemia should include screening for maternal depression and, if indicated, appropriate maternal referral for depression evaluation and treatment. TRIAL REGISTRATION The trial was registered at clinicaltrials.gov (#NCT03634488) on January 30, 2018, https//clinicaltrials.gov/study/NCT03634488 .
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Language: En Journal: BMC Nutr Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Language: En Journal: BMC Nutr Year: 2024 Document type: Article Affiliation country: Country of publication: