Cognition and saccadic eye movement performance are impaired in chronic rhinosinusitis.
Int Forum Allergy Rhinol
; 14(7): 1206-1217, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38268115
ABSTRACT
BACKGROUND:
Patients with chronic rhinosinusitis (CRS) can experience cognitive dysfunction. The literature on this topic mostly reflects patient-reported measurements. Our goal was to assess cognitive function in patients with CRS using objective measures, including saccadic eye movements-a behavioral response reflecting cognitive and sensory information integration that is often compromised in conditions with impaired cognition.METHODS:
Participants (N = 24 with CRS, N = 23 non-CRS healthy controls) enrolled from rhinology clinic underwent sinonasal evaluation, quality of life assessment (Sino-nasal Outcome Test 22 [SNOT-22]), and cognitive assessment with the Neuro-QOL Cognitive Function-Short Form, the Montreal Cognitive Assessment (MoCA), and recording of eye movements using video-oculography.RESULTS:
Participants with CRS were more likely to report cognitive dysfunction (Neuro-QOL; 45.8% vs. 8.7%; p = 0.005) and demonstrate mild or greater cognitive impairment (MoCA; 41.7% vs. 8.7%; p = 0.005) than controls. Additionally, participants with CRS performed worse on the MoCA overall and within the executive functioning and memory domains (all p < 0.05) and on the anti-saccade (p = 0.014) and delay saccade (p = 0.044) eye movement tasks. Poorer performance on the MoCA (r = -0.422; p = 0.003) and the anti-saccade (r = -0.347; p = 0.017) and delay saccade (r = -0.419; p = 0.004) eye movement tasks correlated with worse CRS severity according to SNOT-22 scores.CONCLUSION:
This study is the first to utilize objective eye movement assessments in addition to researcher-administered cognitive testing in patients with CRS. These patients demonstrated a high prevalence of cognitive dysfunction, most notably within executive functioning and memory domains, with the degree of dysfunction correlating with the severity of CRS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saccades
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Sinusitis
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Rhinitis
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Cognition
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Cognitive Dysfunction
Type of study:
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Adult
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Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Int Forum Allergy Rhinol
Year:
2024
Document type:
Article
Affiliation country: