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Gut microb-aging and its relevance to frailty aging.
Le Cosquer, Guillaume; Vergnolle, Nathalie; Motta, Jean-Paul.
Affiliation
  • Le Cosquer G; Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France; Department of Gastroenterology and Pancreatology, Toulouse University Hospital, Toulouse Paul Sabatier University, 31059 Toulouse, France.
  • Vergnolle N; Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Motta JP; Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France. Electronic address: jean-paul.motta@inserm.fr.
Microbes Infect ; 26(3): 105309, 2024.
Article in En | MEDLINE | ID: mdl-38316374
ABSTRACT
This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations in microbiota's taxonomy and metabolism, as well as with concepts of ecological resilience, pathobionts emergence, and biogeography. We examine microb-aging in interconnected body organs, emphasizing the bidirectional relationship with 'inflammaging'. Finally, we discuss how targeting microb-aging could improve screening, diagnostic, and therapeutic approaches in geriatrics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Gastrointestinal Microbiome / Frailty Limits: Humans Language: En Journal: Microbes Infect Journal subject: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Gastrointestinal Microbiome / Frailty Limits: Humans Language: En Journal: Microbes Infect Journal subject: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: