Mannose Ligands for Mannose Receptor Targeting.
Int J Mol Sci
; 25(3)2024 Jan 23.
Article
in En
| MEDLINE
| ID: mdl-38338648
ABSTRACT
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides. Furthermore, multivalent mannose presentation on the various templates like peptides, proteins, polymers, micelles, and dendrimers was proven to be a valuable approach for the selective and efficient delivery of various therapeutically active agents to MR. This review provides a detailed account of the most relevant and recent aspects of the synthesis and application of mannosylated bioactive formulations for MR-mediated delivery in treatments of cancer and other infectious diseases. It further highlights recent findings related to the necessary structural features of the mannose-containing ligands for successful binding to the MR.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mannose Receptor
/
Mannose
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Document type:
Article
Affiliation country: