Genomic island-encoded regulatory proteins in enterohemorrhagic Escherichia coli O157:H7.
Virulence
; 15(1): 2313407, 2024 12.
Article
in En
| MEDLINE
| ID: mdl-38357901
ABSTRACT
Enterohemorrhagic Escherichia coli (EHEC) is an important zoonotic pathogen that is a major cause of foodborne diseases in most developed and developing countries and can cause uncomplicated diarrhoea, haemorrhagic colitis, and haemolytic uraemic syndrome. O islands (OIs), which are unique genomic islands in EHEC O157H7, are composed of 177 isolated genomic features and harbour 26% of the total genes that are absent in the non-pathogenic E. coli K-12 genome. In the last twenty years, many OI-encoded proteins have been characterized, including proteins regulating virulence, motility, and acid resistance. Given the critical role of regulatory proteins in the systematic and hierarchical regulation of bacterial biological processes, this review summarizes the OI-encoded regulatory proteins in EHEC O157H7 characterized to date, emphasizing OI-encoded regulatory proteins for bacterial virulence, motility, and acid resistance. This summary will be significant for further exploration and understanding of the virulence and pathogenesis of EHEC O157H7.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Escherichia coli O157
/
Escherichia coli Proteins
/
Escherichia coli Infections
/
Enterohemorrhagic Escherichia coli
Limits:
Humans
Language:
En
Journal:
Virulence
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: