Monocyte distribution width (MDW): study of reference values in blood donors.
Clin Chem Lab Med
; 62(6): 1133-1137, 2024 May 27.
Article
in En
| MEDLINE
| ID: mdl-38369513
ABSTRACT
OBJECTIVES:
Monocyte distribution width (MDW) is a new biomarker used as an early indicator of sepsis (ESId). It is often aids in the identification of patients who may develop sepsis. This study aims to establish the MDW reference interval (RI) within the healthy population of blood donors using EDTA-K2 as anticoagulant. Many hospitals use this biomarker as a means of identifying patients who present to the hospital with sepsis.METHODS:
A total of 274 samples obtained from healthy donors were analyzed. MDW measurements were taken within 2â¯h post-extraction. The RI was estimated using various statistical methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric and robust methods, along with the Harrell-Davis bootstrap method applied to the entire sample.RESULTS:
The RI estimated through non-parametric method was 14.77 CI90â¯% (14.36-14.97)-21.13 CI90â¯% (20.89-21.68); RI using the robust method was 15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90â¯% (14.53-14.92)-21.14 CI90â¯% (20.88-21.40).CONCLUSIONS:
Based on clinical applicability, we recommend utilizing the RI derived from the non-parametric method, aligning with the CLSI recommendations. Furthermore, we consider that our results can be taken as a reference in other laboratories that serve a population similar to our study cohort.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Donors
/
Monocytes
Limits:
Adolescent
/
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Clin Chem Lab Med
/
Clin. chem. lab. med
/
Clinical chemistry and laboratory medicine
Journal subject:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: