Enteral supplementation with arachidonic and docosahexaenoic acid and pulmonary outcome in extremely preterm infants.
Prostaglandins Leukot Essent Fatty Acids
; 201: 102613, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38377640
ABSTRACT
Enteral supplementation with arachidonic acid (AA) and docosahexaenoic acid (DHA) in extremely preterm infants has shown beneficial effects on retinopathy of prematurity and pulmonary outcome whereas exclusive DHA supplementation has been associated with increased pulmonary morbidity. This secondary analysis evaluates pulmonary outcome in 204 extremely preterm infants, randomized to receive AA (100 mg/kg/day) and DHA (50 mg/kg/day) enterally from birth until term age or standard care. Pulmonary morbidity was primarily assessed based on severity of bronchopulmonary dysplasia (BPD). Serum levels of AA and DHA during the first 28 days were analysed in relation to BPD. Supplementation with AADHA was not associated with increased BPD severity, adjusted OR 1.48 (95 % CI 0.85-2.61), nor with increased need for respiratory support at post menstrual age 36 weeks or duration of oxygen supplementation. Every 1 % increase in AA was associated with a reduction of BPD severity, adjusted OR 0.73 (95 % CI 0.58-0.92). In conclusion, in this study, with limited statistical power, enteral supplementation with AADHA was not associated with an increased risk of pulmonary morbidity, but higher levels of AA were associated with less severe BPD. Whether AA or the combination of AA and DHA have beneficial roles in the immature lung needs further research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bronchopulmonary Dysplasia
/
Docosahexaenoic Acids
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Arachidonic Acid
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Dietary Supplements
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Infant, Extremely Premature
Limits:
Female
/
Humans
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Male
/
Newborn
Language:
En
Journal:
Prostaglandins Leukot Essent Fatty Acids
Journal subject:
ENDOCRINOLOGIA
Year:
2024
Document type:
Article