On the ever-growing functional versatility of the CRISPR-Cas13 system.
Microb Biotechnol
; 17(2): e14418, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38381083
ABSTRACT
CRISPR-Cas systems evolved in prokaryotes to implement a powerful antiviral immune response as a result of sequence-specific targeting by ribonucleoproteins. One of such systems consists of an RNA-guided RNA endonuclease, known as CRISPR-Cas13. In very recent years, this system is being repurposed in different ways in order to decipher and engineer gene expression programmes. Here, we discuss the functional versatility of the CRISPR-Cas13 system, which includes the ability for RNA silencing, RNA editing, RNA tracking, nucleic acid detection and translation regulation. This functional palette makes the CRISPR-Cas13 system a relevant tool in the broad field of systems and synthetic biology.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prokaryotic Cells
/
CRISPR-Cas Systems
Language:
En
Journal:
Microb Biotechnol
/
Microb. biotechnol. (Online)
/
Microbial biotechnology (Online)
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: