18ß-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis.
Cancer Chemother Pharmacol
; 93(6): 575-585, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38383823
ABSTRACT
PURPOSE:
18ß-glycyrrhetinic acid (GA), the main metabolite of glycyrrhizic acid extracted from the root of licorice, has been reported to possess anti-cancer and immunomodulatory activity, but the mechanisms are not well understood. Recent studies have shown that ferroptosis of immune cells is involved in tumor-associated immune suppression. The purpose of this study was to investigate whether the enhanced immune response via inhibiting immune cell ferroptosis contributed to the anticancer effect of 18ß-GA.METHODS:
Lewis Lung carcinoma mouse model and Murine CD8 + T cell culture model were used to examine the changes of immune response and ferroptosis of immune cells.RESULTS:
We found that 18ß-GA was effective against lung cancer accompanied by enhanced activation of tumor-infiltrating CD8+ T cells in Lewis Lung carcinoma mouse model. Furthermore, we demonstrated that the boosted immune response by GA was attributed to its ability to inhibit arachidonic acid (AA)-mediated CD8+ T ferroptosis via suppressing CD36 expression.CONCLUSION:
The findings of the present study unraveled a novel mechanism underlying the anti-cancer and immunomodulatory activity of 18ß-GA and support that 18ß-GA holds potential to be used as an immune enhancer for lung cancer prevention or treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CD8-Positive T-Lymphocytes
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Carcinoma, Lewis Lung
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Ferroptosis
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Glycyrrhetinic Acid
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Mice, Inbred C57BL
Limits:
Animals
Language:
En
Journal:
Cancer Chemother Pharmacol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication:
ALEMANHA
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ALEMANIA
/
DE
/
DEUSTCHLAND
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GERMANY