Your browser doesn't support javascript.
loading
Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer.
Zhang, Zehua; Zhang, Yuqin; Hu, Feixiang; Xie, Tiansong; Liu, Wei; Xiang, Huijing; Li, Xiangxiang; Chen, Lei; Zhou, Zhengrong.
Affiliation
  • Zhang Z; Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106, Ruili Road, 201100, Shanghai, China.
  • Zhang Y; Department of Colorectal Surgery, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106, Ruili Road, 201100, Shanghai, China.
  • Hu F; Department of Radiology, Fudan University Shanghai Cancer Center, No. 270, Dongan Road, 200032, Shanghai, China.
  • Xie T; Department of Radiology, Fudan University Shanghai Cancer Center, No. 270, Dongan Road, 200032, Shanghai, China.
  • Liu W; Department of Radiology, Fudan University Shanghai Cancer Center, No. 270, Dongan Road, 200032, Shanghai, China.
  • Xiang H; Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106, Ruili Road, 201100, Shanghai, China.
  • Li X; Nursing department, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106. Ruili Road, 201100, Shanghai, China.
  • Chen L; Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106, Ruili Road, 201100, Shanghai, China. mac_chenlei@126.com.
  • Zhou Z; Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer Center, No. 106, Ruili Road, 201100, Shanghai, China. zhouzr-16@163.com.
Cancer Imaging ; 24(1): 29, 2024 Feb 26.
Article in En | MEDLINE | ID: mdl-38409049
ABSTRACT

OBJECTIVE:

To investigate the diagnostic value of diffusion kurtosis magnetic resonance imaging (DKI) and conventional diffusion-weighted imaging (DWI) for evaluating the response to first-line chemotherapy in unresectable pancreatic cancer. MATERIALS AND

METHODS:

We retrospectively analyzed 21 patients with clinically and pathologically confirmed unresected pancreatic cancer who received palliative chemotherapy. Three-tesla MRI examinations containing DWI sequences with b values of 0, 100, 700, 1400, and 2100 s/mm2 were performed before and after chemotherapy. Parameters included the apparent diffusion coefficient (ADC), mean diffusion coefficient (MD), and mean diffusional kurtosis (MK). The performances of the DWI and DKI parameters in distinguishing the response to chemotherapy were evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Overall survival (OS) was calculated from the date of first treatment to the date of death or the latest follow-up date.

RESULTS:

The ADCchange and MDchange were significantly higher in the responding group (PR group) than in the nonresponding group (non-PR group) (ADCchange 0.21 ± 0.05 vs. 0.11 ± 0.09, P = 0.02; MDchange 0.37 ± 0.24 vs. 0.10 ± 0.12, P = 0.002). No statistical significance was shown when comparing ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost between the PR and non-PR groups. The ROC curve analysis indicated that MDchange (AUC = 0.898, cutoff value = 0.7143) performed better than ADCchange (AUC = 0.806, cutoff value = 0.1369) in predicting the response to chemotherapy.

CONCLUSION:

The ADCchange and MDchange demonstrated strong potential for evaluating the response to chemotherapy in unresectable pancreatic cancer. The MDchange showed higher specificity in the classification of PR and non-PR than the ADCchange. Other parameters, including ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost, are not suitable for response evaluation. The combined model SUMchange demonstrated superior performance compared to the individual DWI and DKI models. Further experiments are needed to evaluate the potential of DWI and DKI parameters in predicting the prognosis of patients with unresectable pancreatic cancer.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Diffusion Tensor Imaging Limits: Humans Language: En Journal: Cancer Imaging Journal subject: DIAGNOSTICO POR IMAGEM / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Diffusion Tensor Imaging Limits: Humans Language: En Journal: Cancer Imaging Journal subject: DIAGNOSTICO POR IMAGEM / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication: