Recent Progress in Site-Selective Modification of Peptides and Proteins Using Macrocycles.
Bioconjug Chem
; 35(3): 277-285, 2024 Mar 20.
Article
in En
| MEDLINE
| ID: mdl-38417023
ABSTRACT
Peptides and proteins undergo crucial modifications to alter their physicochemical properties to expand their applications in diverse fields. Various techniques, such as unnatural amino acid incorporation, enzyme catalysis, and chemoselective methods, have been employed for site-selective peptide and protein modification. While traditional methods remain valuable, advancement in host-guest chemistry introduces innovative and promising approaches for the selective modification of peptides and proteins. Macrocycles exhibit robust binding affinities, particularly with natural amino acids, which facilitates their use in selectively binding to specific sequences. This distinctive property endows macrocycles with the potential for modification of target peptides and proteins. This review provides a comprehensive overview of strategies utilizing macrocycles for the selective modification of peptides and proteins. These strategies unlock new possibilities for constructing antibody-drug conjugates and stabilizing volatile medications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Proteins
Language:
En
Journal:
Bioconjug Chem
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country: