Recent advances in modelling Shigella infection.
Trends Microbiol
; 32(9): 917-924, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38423917
ABSTRACT
Shigella is an important human-adapted pathogen which contributes to a large global burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance and lack of an effective vaccine, there is great urgency to identify novel therapeutics and preventatives to combat Shigella infection. In this review, we discuss the development of innovative technologies and animal models to study mechanisms underlying Shigella infection of humans. We examine recent literature introducing (i) the organ-on-chip model, and its substantial contribution towards understanding the biomechanics of Shigella infection, (ii) the zebrafish infection model, which has delivered transformative insights into the epidemiological success of clinical isolates and the innate immune response to Shigella, (iii) a pioneering oral mouse model of shigellosis, which has helped to discover new inflammasome biology and protective mechanisms against shigellosis, and (iv) the controlled human infection model, which has been effective in translating basic research into human health impact and assessing suitability of novel vaccine candidates. We consider the recent contributions of each model and discuss where the future of modelling Shigella infection lies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shigella
/
Zebrafish
/
Disease Models, Animal
/
Dysentery, Bacillary
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Microbiol
/
Trends in microbiology
/
Trends microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Document type:
Article
Country of publication: