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Fecal Microbiota Transplantation in Amyotrophic Lateral Sclerosis: Clinical Protocol and Evaluation of Microbiota Immunity Axis.
Niccolai, Elena; Martinelli, Ilaria; Quaranta, Gianluca; Nannini, Giulia; Zucchi, Elisabetta; De Maio, Flavio; Gianferrari, Giulia; Bibbò, Stefano; Cammarota, Giovanni; Mandrioli, Jessica; Masucci, Luca; Amedei, Amedeo.
Affiliation
  • Niccolai E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Martinelli I; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Quaranta G; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
  • Nannini G; Department of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, Rome, Italy.
  • Zucchi E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • De Maio F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gianferrari G; Department of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, Rome, Italy.
  • Bibbò S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Cammarota G; Digestive Disease Center, A. Gemelli University Hospital IRCCS, Catholic University of Sacred Heart, Rome, Italy.
  • Mandrioli J; Digestive Disease Center, A. Gemelli University Hospital IRCCS, Catholic University of Sacred Heart, Rome, Italy.
  • Masucci L; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Amedei A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Methods Mol Biol ; 2761: 373-396, 2024.
Article in En | MEDLINE | ID: mdl-38427251
ABSTRACT
The fecal microbial transplantation (FMT) is a therapeutic transplant of fecal microbiota from healthy donors to patients. This practice is aimed at restoring eubiosis and rebalancing the enteric and systemic immune responses, and then eliminating pathogenic triggers of multiple disease, including neurodegenerative diseases. Alterations of gut microbiota (GM) affect the central nervous system (CNS) health, impacting neuro-immune interactions, synaptic plasticity, myelination, and skeletal muscle function. T-regulatory lymphocytes (Treg) are among the most important players in the pathogenesis of amyotrophic lateral sclerosis (ALS), altering the disease course. Along with circulating neuropeptides, other immune cells, and the gut-brain axis, the GM influences immunological tolerance and controls Treg's number and suppressive functions. A double-blind, controlled, multicenter study on FMT in ALS patients has been designed to evaluate if FMT can modulate neuroinflammation, by restoring Treg number, thus modifying disease activity and progression.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbiota / Gastrointestinal Microbiome / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbiota / Gastrointestinal Microbiome / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Country of publication: