Polyacetylenes from Saposhnikovia divaricata and their anticancer activity.
Fitoterapia
; 174: 105876, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38431027
ABSTRACT
Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 µM against HEPG2.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apiaceae
/
Polyynes
Limits:
Humans
Language:
En
Journal:
Fitoterapia
Year:
2024
Document type:
Article
Country of publication: