Endothelial lipid droplets drive atherosclerosis and arterial hypertension.

Xu, Suowen; Offermanns, Stefan

Xu, Suowen; Offermanns, Stefan.

Affiliation

Xu S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany; Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: Suowen.Xu@mpi-bn.mpg.de.
Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany; Center for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Trends Endocrinol Metab ; 35(6): 453-455, 2024 Jun.

Article in En | MEDLINE | ID: mdl-38431437

ABSTRACT

ABSTRACT

Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.

Subject(s)
Key words

ATGL; DGAT; atherosclerosis; blood pressure; endothelial dysfunction; lipid droplet

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Cells / Atherosclerosis / Lipid Droplets / Hypertension Limits: Animals / Humans Language: En Journal: Trends Endocrinol Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2024 Document type: Article

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